Ator N A
Neurobehav Toxicol Teratol. 1982 Jan-Feb;4(1):51-61.
Behavioral effects of carbon monoxide (CO) were studied in rats during 75-minute exposures in which food reinforcement depended either on 30 lever presses (fixed ratio, FR, 30) or on the first lever press after 3 min (fixed interval, FI, 3 min). Concentrations of 500, 700, and 900 ppm were studied for each rat under at least one of the reinforcement schedules presented singly and under one or more compound schedules (multiple (MULT) FR FI, MULT FR FR, MULT FI FI). Response rates decreased as a function of CO concentrations under all conditions, but overall rate decreases were greater at lower concentrations under the FR schedule than under the FI schedule. Differential effects of CO on the schedule-generated patterns of FR and FI responding were responsible for the differences in rate decreases under those schedules. In some cases, the multiple schedule context attenuated the rate-decreasing effect of CO on FR responding. Differences in magnitude of CO effects were not attributable to previous CO exposures, control response rates, or reinforcement frequency. The extent to which CO disrupts behavior can be a function of the prevailing behavioral contingencies.
在大鼠身上研究了一氧化碳（CO）的行为效应，实验中大鼠在75分钟的暴露期间，食物强化要么取决于30次杠杆按压（固定比率，FR，30），要么取决于3分钟后的第一次杠杆按压（固定间隔，FI，3分钟）。对每只大鼠在至少一种单独呈现的强化程序以及一种或多种复合程序（多重（MULT）FR FI、MULT FR FR、MULT FI FI）下，研究了500、700和900 ppm的浓度。在所有条件下，反应率均随CO浓度的升高而降低，但在FR程序下，较低浓度时的总体反应率下降幅度大于FI程序。CO对FR和FI反应的程序生成模式的不同影响导致了这些程序下反应率下降的差异。在某些情况下，多重程序背景减弱了CO对FR反应的反应率降低效应。CO效应大小的差异不归因于先前的CO暴露、对照反应率或强化频率。CO对行为的干扰程度可能取决于当前的行为偶然性。
