Parenti M, Gentleman S, Olianas M C, Neff N H
Neurochem Res. 1982 Jan;7(1):115-24. doi: 10.1007/BF00965074.
The dopamine receptor adenylate cyclase complex of a rat striatal membrane preparation became more responsive to dopamine following the injection of 6-hydroxydopamine (6-OHDA) into the median forebrain bundle or following the subcutaneous implantation of morphine pellets. Moreover, the membrane cyclase system was more responsive to activation by GTP, guanyl-5'-yl-imidodiphosphate and Mn-ATP. These observations suggest that both 6-OHDA and morphine induce similar biochemical changes in striatum and that the increased responsiveness arises, in part, from modification of the nucleotide regulatory and/or catalytic components of adenylate cyclase.
在将6-羟基多巴胺（6-OHDA）注入中脑前束或皮下植入吗啡微丸后，大鼠纹状体膜制剂中的多巴胺受体 - 腺苷酸环化酶复合物对多巴胺的反应性增强。此外，膜环化酶系统对GTP、鸟苷-5'-亚基-亚氨基二磷酸和锰 - ATP的激活反应性更高。这些观察结果表明，6-OHDA和吗啡在纹状体中诱导相似的生化变化，并且反应性增加部分源于腺苷酸环化酶的核苷酸调节和/或催化成分的改变。
