Barry D I, Paulson O B
Neurosurgery. 1982 Feb;10(2):224-6.
The permeability of the blood-brain barrier (BBB) to methotrexate, Na+, and Cl- was studied in rats treated with the membrane-active antifungal agent amphotericin B. Enhancement of brain uptake of methotrexate was expected as amphotericin B increases the permeability of lipid membranes, including tumor cell membranes. However, amphotericin B had no effect of the BBB permeability to methotrexate, Na+, and Cl-. This may have been because the amphotericin B acted only on the luminal and not on the abluminal brain capillary membrane, leaving the BBB intact.
在接受膜活性抗真菌剂两性霉素B治疗的大鼠中，研究了血脑屏障（BBB）对甲氨蝶呤、Na⁺和Cl⁻的通透性。由于两性霉素B可增加包括肿瘤细胞膜在内的脂质膜的通透性，因此预计甲氨蝶呤的脑摄取会增强。然而，两性霉素B对BBB对甲氨蝶呤、Na⁺和Cl⁻的通透性没有影响。这可能是因为两性霉素B仅作用于管腔侧而非脑毛细血管膜的管腔外侧面，从而使BBB保持完整。
