Christensen R D, Bradley P P, Priebat D A, Anstall H, Rothstein G
Pediatr Res. 1982 Jan;16(1):57-9. doi: 10.1203/00006450-198201001-00011.
Newborn dogs were inoculated intratracheally with 0.5-1.0 X 10(8) Staphylococcus aureus/g body weight. Neutropenia (490 +/- 280 neutrophils/mm 3 versus 8,390 +/- 490 control, mean +/- S.E., P less than 0.001), and depletion of the marrow neutrophil storage pool (3 +/- 1% versus 27 +/- 2% storage neutrophils, P less than 0.001) occurred 5-6 h following the inoculation. All animals died at 6-10 h. Additional inoculated pups were selected at random to receive transfusions of either granulocytes, plasma or red blood cells. Granulocyte transfusions (3 X 10(9) neutrophils/kg) improved survival (P less than 0.005), but plasma and red blood cells did not.
新生犬经气管内接种0.5 - 1.0×10⁸个金黄色葡萄球菌/克体重。接种后5 - 6小时出现中性粒细胞减少（490±280个中性粒细胞/立方毫米，而对照组为8390±490个，均值±标准误，P<0.001），且骨髓中性粒细胞储存池耗竭（储存的中性粒细胞为3±1%，而对照组为27±2%，P<0.001）。所有动物在6 - 10小时死亡。随机选择额外接种的幼犬接受粒细胞、血浆或红细胞输血。粒细胞输血（3×10⁹个中性粒细胞/千克）可提高生存率（P<0.005），但血浆和红细胞输血则不能。
