Herreman G, Betous F, Batisse P, Bessis R, Lesavre P, Ferme I
Nouv Presse Med. 1982 Feb 27;11(9):657-60.
A woman with isolated juvenile Sjögren's syndrome gave birth, at 3 years' interval, to two children with complete atrio-ventricular heart block (AVB). This is the first published case of AVB in children of mothers with Sjögren's syndrome without any clinical and laboratory evidence of connective tissue disease, notably lupus. Ultrasonography showed that the AVB was acquired in utero and occurred during the 23rd week of gestation. In both children the AVB was isolated, without any symptom of congenital malformation of the heart; there were no abnormalities of conduction in the mother. Early corticosteroid treatment of the mother's disease had no beneficial effect on AVB in the foetuses. Attempts to reproduce the condition experimentally met with failure.
一名患有孤立性青少年干燥综合征的女性，间隔3年生育了两个患有完全性房室传导阻滞（AVB）的孩子。这是首例发表的母亲患有干燥综合征但无任何结缔组织病（尤其是狼疮）临床和实验室证据的儿童AVB病例。超声检查显示，AVB是在子宫内获得的，发生在妊娠第23周。两个孩子的AVB均为孤立性，无任何先天性心脏畸形症状；母亲的传导无异常。母亲疾病的早期皮质类固醇治疗对胎儿的AVB没有有益影响。通过实验重现该病症的尝试均告失败。
