Fowler A A, Hyers T M
Postgrad Med. 1982 Apr;71(4):149-54, 158. doi: 10.1080/00325481.1982.11716048.
Thrombolytic agents are effective in acute pulmonary embolism and thrombosis in the popliteal and proximal deep veins. Patients with recent thromboemboli, as manifested by onset of symptoms within the previous five days, respond best. Bleeding complications can be greatly reduced by proper patient selection and by avoidance of invasive procedures. Thrombolytic agents are easily administered, and laboratory monitoring has been simplified. Anticoagulants must be given when thrombolytic therapy is completed, since the thrombotic tendency probably still exists.
溶栓剂对急性肺栓塞以及腘静脉和近端深静脉血栓形成有效。近期有血栓栓塞的患者，即症状在过去五天内出现的患者，反应最佳。通过适当的患者选择和避免侵入性操作，出血并发症可大大减少。溶栓剂易于给药，实验室监测也已简化。溶栓治疗完成后必须给予抗凝剂，因为血栓形成倾向可能仍然存在。
