Taylor A N, Branch B J, Liu S H, Kokka N
Pharmacol Biochem Behav. 1982 Apr;16(4):585-9. doi: 10.1016/0091-3057(82)90420-8.
Pregnant female rats were fed either a 5.0-5.5% w/v ethanol-containing liquid diet ad lib or pair-fed the isocaloric control diet during gestation weeks 2 and 3. At 75-105 days of age, female offspring of the ethanol-treated dams showed significantly greater corticosterone responses than pair-fed- or normally-derived offspring to the stress of cardiac puncture or of noise and shaking, while pituitary-adrenal responses to exposure to a novel environment, cold or 2-3 days of fasting were normal. Adrenal sensitivity to ACTH in dexamethasone-suppressed adult offspring was unaffected by the prenatal treatment. The results demonstrate that fetal ethanol exposure enhances adult pituitary-adrenal responses to certain stressors, including alcohol as demonstrated previously, and suggest that the long-term effects may be mediated by developmental actions of alcohol on central neural mechanisms involved in the regulation of this neuroendocrine system.
在妊娠第2和第3周，给怀孕的雌性大鼠随意喂食含5.0 - 5.5%（重量/体积）乙醇的液体饲料，或给其配对喂食等热量的对照饲料。在75 - 105日龄时，经乙醇处理的母鼠所生的雌性后代，对心脏穿刺、噪音和摇晃等应激源的皮质酮反应，比配对喂食组或正常来源的后代明显更强，而对暴露于新环境、寒冷或禁食2 - 3天的垂体 - 肾上腺反应则正常。产前处理对成年后代在地塞米松抑制下肾上腺对促肾上腺皮质激素（ACTH）的敏感性没有影响。结果表明，胎儿期乙醇暴露会增强成年垂体 - 肾上腺对某些应激源的反应，包括如先前所示的酒精，并且提示长期影响可能是由酒精对参与该神经内分泌系统调节的中枢神经机制的发育作用所介导的。
