Weinberg J, Gallo P V
Neurobehav Toxicol Teratol. 1982 Sep-Oct;4(5):515-20.
Pregnant Sprague-Dawley females were assigned to one of three treatments: liquid diet with ethanol (5.5% w/v), ad lib; liquid control diet, pair-fed to alcohol group; pelleted control diet, ad lib. On day 19 of gestation females consuming ethanol exhibited greater corticoid elevations than controls at 30 min following stress. Pair-fed females were similar to controls at 30 min, but did not exhibit the return toward basal levels shown by both ethanol and control females at 90 min following stress. Thus ethanol consumption during pregnancy produced an enhanced stress response, while pair-feeding during pregnancy produced prolonged corticoid activation following stress. In offspring tested at 39 days of age, no sex differences occurred in the plasma corticoid stress response of nonhandled animals from any of the 3 diet groups. However in handled animals, it was observed that females prenatally exposed to ethanol exhibited higher corticosterone levels than alcohol-exposed males. Thus prenatal dietary treatment appeared to interact with postnatal handling experience to influence the development of the pituitary-adrenal system.
将怀孕的斯普拉格-道利雌性大鼠分为三组进行处理：含乙醇的流质饮食（5.5% w/v），随意进食；流质对照饮食，与乙醇组配对喂养；颗粒状对照饮食，随意进食。在妊娠第19天，摄入乙醇的雌性大鼠在应激后30分钟时皮质激素升高幅度大于对照组。配对喂养的雌性大鼠在30分钟时与对照组相似，但在应激后90分钟时未表现出乙醇组和对照组雌性大鼠所呈现的恢复至基础水平的情况。因此，孕期摄入乙醇会增强应激反应，而孕期配对喂养会使应激后皮质激素激活时间延长。在39日龄时对后代进行测试，三个饮食组中未经处理的动物的血浆皮质激素应激反应不存在性别差异。然而，在经过处理的动物中，观察到产前暴露于乙醇的雌性大鼠的皮质酮水平高于暴露于乙醇的雄性大鼠。因此，产前饮食处理似乎与产后处理经历相互作用，从而影响垂体-肾上腺系统的发育。
