Labrecque G, Bélanger P M, Doré F
Pharmacology. 1982;24(3):169-74. doi: 10.1159/000137592.
Circannual variation in the edema produced by intraplantar injection of carrageenan (carr) was examined over a period of 31 months. The anti-inflammatory effect of a dose of 30 mg/kg of phenylbutazone (PHZ) was also determined over a period of 1 year. Carr-induced edema was significantly larger in spring while it was smaller in winter. PHZ induced a pronounced reduction of paw edema throughout the year except in spring when the anti-inflammatory effect of the drug could not be detected. Mechanisms responsible for these circannual variations are discussed.
在31个月的时间里，研究了足底注射角叉菜胶（carr）所致水肿的年周期变化。在1年的时间里，还测定了30mg/kg剂量保泰松（PHZ）的抗炎作用。角叉菜胶诱导的水肿在春季显著增大，而在冬季则较小。除春季未检测到该药的抗炎作用外，保泰松在全年均可显著减轻爪部水肿。文中讨论了这些年周期变化的相关机制。
