Buczko W
Acta Physiol Pol. 1978 May-Jun;29(3):259-66.
Investigations were carried out in vitro and in vivo on the effects of FDP on the rat heart. It was found that FDP have a positive chronotropic and inotropic effect. In in vivo investigations it was shown that the peptides raise the activity of phosphorylase a in the heart and increase slightly blood FFA and lactate levels decreasing glycogen content in the myocardium. The effects of the examined peptides are blocked partly by propranolol and reserpine, while phentolamine failed to change the FDP action. These data suggest that FDP exert chronotropic and inotropic effects through their action on the beta-adrenergic receptors in the myocardium.
对1,6-二磷酸果糖（FDP）对大鼠心脏的影响进行了体外和体内研究。发现FDP具有正性变时性和变力性作用。体内研究表明，这些肽可提高心脏中磷酸化酶a的活性，略微增加血液中游离脂肪酸（FFA）和乳酸水平，同时降低心肌中的糖原含量。所检测肽的作用部分被普萘洛尔和利血平阻断，而酚妥拉明未能改变FDP的作用。这些数据表明，FDP通过作用于心肌中的β-肾上腺素能受体发挥变时性和变力性作用。
