氟化钠对实验性流感感染小鼠肺匀浆中同工酶谱的影响。
Influence of sodium fluoride on isoenzyme patterns in the lung homogenates of mice with experimental influenza infection.
作者信息
Prahoveanu E, Eşanu V
出版信息
Virologie. 1982 Jan-Mar;33(1):35-8.
PMID:7072148
Abstract
NaF was administered intranasally to mice- either as a single or as four daily 100-gamma doses - prior to inoculation of influenza virus A/PR8/34 (H0N1). The changes caused by drug treatment in the isoenzyme patterns of peroxidase, acid and alkaline phosphatases, succinate and lactate dehydrogenases, observed in the mouse lung homogenates, could not be correlated with the previously recorded NaF-induced reduction in hemagglutinating titers and mortality rate.
摘要
在给小鼠接种甲型流感病毒A/PR8/34（H0N1）之前，通过鼻腔向小鼠施用氟化钠——单次给药或每日4次，每次剂量为100微克。在小鼠肺匀浆中观察到的药物治疗引起的过氧化物酶、酸性和碱性磷酸酶、琥珀酸脱氢酶和乳酸脱氢酶同工酶模式的变化，与先前记录的氟化钠引起的血凝滴度降低和死亡率降低无关。
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