High density lipoprotein composition versus heredity for acute myocardial infarction in middle-aged males.

The levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI (Apo AI) were determined in 299 men, 48 years of age. We found a significant negative correlation between HDL cholesterol and serum triglyceride concentrations and a significant correlation between serum triglyceride concentration and the Apo AI/HDL cholesterol ratio. A history of acute myocardial infarction (AMI) was significantly more common than expected among the fathers of men with a low HDL cholesterol level. We also found a relationship between AMI among fathers and high Apo AI level in sons, although this relationship was not as strong as that between AMI among fathers and low HDL cholesterol in sons. No significant relationship was found between AMI among mothers and HDL cholesterol or Apo AI in sons.