Friendly D S, Font R L, Milhorat T H
Am J Ophthalmol. 1982 Apr;93(4):482-90. doi: 10.1016/0002-9394(82)90138-6.
Radiographic studies disclosed that a 5-year-old girl with proptosis and inferior displacement of her left globe had a lytic lesion in the superior orbital rim. Tissue removed at the time of the initial biopsy was not sufficiently distinctive for a definitive diagnosis, but microscopic examination of residual tumor clearly established the diagnosis of hemangioendothelioma of the frontal bone. Electron microscopic studies demonstrated that the vascular structures, which resembled endothelium, contained many thin microfilaments and mitochondria and scattered dense bodies. Each vessel was surrounded by a prominent mantle of pericytes.
影像学研究显示，一名5岁左眼眼球突出并向下移位的女孩，其眶上缘有一个溶骨性病变。初次活检时切除的组织特征不足以明确诊断，但对残留肿瘤的显微镜检查明确诊断为额骨血管内皮瘤。电子显微镜研究表明，类似内皮细胞的血管结构含有许多细微丝、线粒体和散在的致密小体。每个血管周围都有一层明显的周细胞套。
