Devereux D F, Wilson R E, Carson J M, Antman K H, Greenberger J S
Am J Surg. 1982 Apr;143(4):490-4. doi: 10.1016/0002-9610(82)90201-x.
Nineteen patients who have undergone surgical resection of low grade soft tissue sarcomas were retrospectively reviewed. Four patients received additional radiation therapy, and 15 did not. Of the 15 patients treated by surgery alone, 4 had positive margins in the original specimen; all 4 had local recurrence within a mean of 42 months. Eleven patients had negative margins. Ten have had no recurrence in a mean of 40 months. One patient had local recurrence at 36 months. Two of the four patients with positive margins were reoperated on and in achieving negative margins have remained disease-free a mean of 84 months. Three patients receiving additional postoperative radiation therapy had positive margins, and all had recurrence in a mean of 36 months. One patient with negative margins who also received radiation therapy is disease-free at 144 months. It appears that tumor-positive margins are associated with a high likelihood of local recurrence, whereas negative margins appear associated with a long disease-free interval and possible cure. Radiation therapy to positive margins did not prevent local recurrence.
对19例接受低度软组织肉瘤手术切除的患者进行了回顾性研究。4例患者接受了额外的放射治疗，15例未接受。在仅接受手术治疗的15例患者中，4例在原始标本中切缘阳性；这4例患者均在平均42个月内出现局部复发。11例患者切缘阴性。10例患者在平均40个月内未复发。1例患者在36个月时出现局部复发。4例切缘阳性患者中的2例接受了再次手术，在切缘变为阴性后，平均84个月无疾病复发。3例接受额外术后放射治疗的患者切缘阳性，均在平均36个月时复发。1例切缘阴性且接受了放射治疗的患者在144个月时无疾病复发。似乎肿瘤切缘阳性与局部复发的高可能性相关，而切缘阴性似乎与较长的无病间期和可能的治愈相关。对切缘阳性患者进行放射治疗并不能预防局部复发。
