Sellers A F, Lowe J E, Drost C J, Rendano V T, Georgi J R, Roberts M C
Am J Vet Res. 1982 Mar;43(3):390-6.
The circular and longitudinal muscle coats of equine "midcolon" were found to be directly electrically coupled. They appear to act in concert, in healthy animals, as a pacemaker in the area of the large colon pelvic flexure, for retropulsive-propulsive myoelectrical events. The retropulsive events keep the cecum and right ventral and left ventral divisions of the colon filled, imposing a delay time for fermentation of cellulose and for bacterial protein synthesis. Point-to-point involvement of adjacent colon sections was slowed by cooling the intestinal contents with no adverse clinical signs. Diminution of the blood flow to this regulatory area was achieved in 12 weanling foals (raised parasite-free) by parasitic cranial mesenteric arteritis, using Strongylus vulgaris larvae. Four of the 12 developed clinical signs of abdominal pain, but on necropsy 3 of these 4 had no gross lesions in the gastrointestinal tract. Dissociation of the left ventral and left dorsal colon divisions, as regards intraluminal pressure events and their antecedent myoelectrical action potentials, was induced in 7 of 8 adult animals given an acaricide which under field conditions is associated with progressive large colon obstruction and colic.
研究发现马“结肠中段”的环行肌层和纵行肌层存在直接电耦合。在健康动物中，它们似乎协同作用，作为大结肠骨盆弯曲处的起搏器，引发逆行推进性肌电活动。逆行事件使盲肠以及结肠的右腹侧和左腹侧部分保持充盈状态，为纤维素发酵和细菌蛋白质合成设置延迟时间。通过冷却肠内容物，相邻结肠段的点对点参与减缓，且无不良临床症状。在12匹断奶幼驹（无寄生虫饲养）中，利用普通圆线虫幼虫引发寄生性肠系膜前动脉炎，减少了该调节区域的血流。12匹马中有4匹出现腹痛临床症状，但尸检时这4匹马中有3匹胃肠道无明显病变。在8只成年动物中，有7只在给予一种杀螨剂后，其左腹侧和左背侧结肠段在腔内压力事件及其先前的肌电动作电位方面出现分离，在野外条件下，这种杀螨剂与进行性大结肠梗阻和绞痛有关。
