Derksen F J, Robinson N E, Slocombe R F, Riebold T W, Brunson D B
Am J Vet Res. 1982 Apr;43(4):598-602.
Arterial blood gas tensions, pulmonary mechanics, and lung volumes were measured in 4 sedated ponies every hour for 6 hours and in 5 ponies 4 times at 2-month intervals to assess the short- and long-term reproducibility of pulmonary function measurements. Variability in blood gas tensions was small over the short- and long-term measurement periods, whereas the variability in total respiratory resistance and functional residual capacity was small over the short term but larger over the long term. The variability in tidal volume, minute ventilation, respiratory rate, and dynamic and quasistatic compliance was relatively large over the short and long term. When data from 5 ponies were pooled, significant change did not occur in any of the variables over a 6-month period. Vagal blockade increased tidal volume and decreased respiratory rate and total respiratory resistance, but arterial blood gas tensions, minute ventilation, dynamic compliance, quasistatic compliance, functional residual capacity, and lung and thoracic cage pressure-volume curves were unaffected. Total respiratory resistance decreased with increasing lung volume, with the vagus intact. After vagal blockade, the decrease in total respiratory resistance with lung volume was minimal. Dynamic compliance was frequency independent over a range of 15 to 60 breaths/min-1, suggesting that measurable inhomogeneity of peripheral time constants did not exist in our clinically normal ponies.
对4匹镇静的矮种马每小时测量1次动脉血气张力、肺力学和肺容量，持续6小时；对5匹矮种马每隔2个月测量4次，以评估肺功能测量的短期和长期可重复性。在短期和长期测量期间，血气张力的变异性较小，而总呼吸阻力和功能残气量的变异性在短期内较小，但在长期内较大。潮气量、分钟通气量、呼吸频率以及动态和准静态顺应性的变异性在短期和长期内相对较大。当汇总5匹矮种马的数据时，在6个月的时间内，任何变量均未发生显著变化。迷走神经阻断使潮气量增加，呼吸频率和总呼吸阻力降低，但动脉血气张力、分钟通气量、动态顺应性、准静态顺应性、功能残气量以及肺和胸廓压力-容积曲线未受影响。在迷走神经完整的情况下，总呼吸阻力随肺容量增加而降低。迷走神经阻断后，总呼吸阻力随肺容量的降低最小。动态顺应性在15至60次呼吸/分钟的范围内与频率无关，这表明在我们临床正常的矮种马中不存在可测量的外周时间常数不均匀性。
