Mazzocchi G, Neri G, Robba C, Belloni A S, Mussdorfer G G
Am J Anat. 1978 Sep;153(1):67-79. doi: 10.1002/aja.1001530105.
The effects of chloramphenicol (CAP) on rat adrenocortical cells were investigated by biochemical and stereological methods. It was found that administering 50mg/kg of CAP every 12 hours provoked a persistent inhibition of the incorporation of 3H-leucine into mitochondrial proteins. Chronic treatment (up to 15 consecutive days) with this dose of CAP induced a significant decrease in the volume of the mitochondrial compartment, in the surface area of the outer and inner mitochondrial membranes and in the number of mitochondria per cell. These results confirm the hypothesis that the ACTH-induced maintenance of adrenocortical mitochondrial growth requires continuous mitochondrial DNA-dependent protein synthesis.
通过生化和体视学方法研究了氯霉素（CAP）对大鼠肾上腺皮质细胞的影响。发现每12小时给予50mg/kg的CAP会持续抑制3H-亮氨酸掺入线粒体蛋白。用此剂量的CAP进行慢性治疗（长达连续15天）导致线粒体区室体积、线粒体外膜和内膜表面积以及每个细胞中线粒体数量显著减少。这些结果证实了以下假设，即促肾上腺皮质激素诱导的肾上腺皮质线粒体生长维持需要持续的线粒体DNA依赖性蛋白质合成。
