氯霉素对促肾上腺皮质激素对大鼠肾上腺皮质细胞长期营养作用的影响：一项体视学与酶学相结合的研究
Effects of chloramphenicol on the long term trophic action of ACTH on rat adrenocortical cells: a combined stereological and enzymological study.
作者信息
Mazzocchi G, Nussdorfer G G
出版信息
J Anat. 1985 Jun;140 ( Pt 4)(Pt 4):607-12.
Abstract
Chronic chloramphenicol administration was found to block the ACTH-induced increase in both the surface area of mitochondrial cristae and the activity of 11 beta-hydroxylase in zona fasciculata cells of the rat adrenal cortex. The surface area of agranular endoplasmic reticulum membranes and the activity of 3 beta-hydroxysteroid dehydrogenase were not affected by treatment with chloramphenicol. These findings suggest that the mechanism of the ACTH-induced enhancement of the growth and steroidogenic capacity of rat adrenocortical cells involves stimulation of mitochondrial DNA-dependent protein synthesis.
摘要
研究发现，长期给予氯霉素会阻断促肾上腺皮质激素（ACTH）诱导的大鼠肾上腺皮质束状带细胞线粒体嵴表面积增加以及11β-羟化酶活性增强。氯霉素处理对无颗粒内质网膜表面积和3β-羟类固醇脱氢酶活性没有影响。这些发现表明，ACTH诱导大鼠肾上腺皮质细胞生长和类固醇生成能力增强的机制涉及刺激线粒体DNA依赖性蛋白质合成。
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