Tan Y O, Woo K T, Chiang G S, Pwee H S, Yeo P P, Khoo O T
Ann Acad Med Singap. 1982 Jan;11(1):57-60.
The nephrotic syndrome complicating malignancy is an unusual occurrence. We report here four cases of nephrotic syndrome associated with malignant tumours. Three cases were associated with bronchogenic carcinoma and one with adenocarcinoma of colon. One of the four cases developed nephrotic syndrome before the discovery of bronchogenic carcinoma. All patients had renal biopsies with light microscopy, immunofluorescence and electron microscopy. The findings suggest an immune-complex disease complicating malignancy. The true incidence of nephrotic syndrome associated with malignant tumours is unknown. However it is clinically prudent to screen for malignancy in older patients presenting with nephrotic syndrome.
恶性肿瘤并发肾病综合征是一种罕见的情况。我们在此报告4例与恶性肿瘤相关的肾病综合征病例。其中3例与支气管肺癌有关，1例与结肠癌有关。4例中有1例在支气管肺癌被发现之前就出现了肾病综合征。所有患者均接受了肾活检，包括光镜、免疫荧光和电镜检查。结果提示这是一种并发于恶性肿瘤的免疫复合物疾病。与恶性肿瘤相关的肾病综合征的真实发病率尚不清楚。然而，对于出现肾病综合征的老年患者，临床上谨慎地筛查恶性肿瘤是明智的。
