Bakker W, Nijhuis-Heddes J M, Brutel de la Rivière A, Dijkman J H
Ann Thorac Surg. 1982 Mar;33(3):267-72. doi: 10.1016/s0003-4975(10)61923-6.
Sixty-four patients received bacillus Calmette- Guérin (BCG) in different dosages intrapleurally through a chest drain following resection for lung cancer. In 27 patients this procedure was followed by fever for a few days; the fever was attributed to the BCG. Late complications attributable to the BCG included recurrent fever in 4 patients, abscesses at the site of the drain in 4, wound infections in 2, consolidations on the chest roentgenogram in 3, 1 of whom had subsequent cavitation, and hemoptysis in 2. Side-effects were not dose-dependent. No relationship was found between the preoperative tuberculin response and the frequency or severity of complications. Treatment with isoniazid and rifampin failed to induce an apparent clinical response in patients with complications. We conclude that the intrapleural administration of BCG is not a safe procedure. The side-effects may considerably impair the patient's quality of life.
64例肺癌切除术后患者通过胸腔引流管接受了不同剂量的卡介苗（BCG）胸膜腔内注射。27例患者在该操作后出现了持续数天的发热，发热被归因于卡介苗。卡介苗所致的晚期并发症包括4例患者反复发热、4例引流部位脓肿、2例伤口感染、3例胸部X线片显示肺实变（其中1例随后出现空洞形成）以及2例咯血。副作用与剂量无关。未发现术前结核菌素反应与并发症的发生率或严重程度之间存在关联。异烟肼和利福平治疗对有并发症的患者未能诱导出明显的临床反应。我们得出结论，胸膜腔内注射卡介苗并非安全的操作。这些副作用可能会严重损害患者的生活质量。
