Ladd H W, Broman H, O'Riain M D
Arch Phys Med Rehabil. 1982 Mar;63(3):124-9.
The objective of this study was to evaluate a new quantitative electrophysiologic method and instrumentation for assessing the regenerative process in peripheral nerve injuries. The method was based on spectrum analysis of myoelectric signals. Myoelectric data were obtained longitudinally from affected muscles of the upper limb in patients with traumatic brachial plexus injuries, and quantitatively subjected to on-line analysis. Bipolar surface recordings were made during voluntarily mediated motor unit activity at both a low level of activity (nonfatiguing state) and a maximal level (fatiguing state). The results over time for the low-level activity have shown a significant increase in mean frequency of the myoelectric signal in some muscles, a significant decrease in other muscles, and no change in still other muscles. A significant increase in amplitude was observed in every instance. During the maximal level of activity there was a reduction in mean frequency and the amount of reduction was shown to increase over time. The results are useful in indicating the occurrence of peripheral sprouting, axonal regrowth, of central reorganization, and in indicating improved metabolic activity in a muscle. It is concluded that the method is reliable in the study of the regenerative process.
本研究的目的是评估一种用于评估周围神经损伤再生过程的新型定量电生理方法及仪器。该方法基于肌电信号的频谱分析。从创伤性臂丛神经损伤患者上肢受影响肌肉纵向获取肌电数据，并对其进行定量在线分析。在低活动水平（非疲劳状态）和最大活动水平（疲劳状态）下，在自主介导的运动单位活动期间进行双极表面记录。低水平活动随时间的结果显示，一些肌肉的肌电信号平均频率显著增加，其他肌肉显著降低，还有一些肌肉无变化。在每种情况下均观察到振幅显著增加。在最大活动水平时，平均频率降低，且降低量随时间增加。这些结果有助于表明周围神经发芽、轴突再生、中枢重组的发生情况，并表明肌肉代谢活动改善。得出的结论是，该方法在再生过程研究中是可靠的。
