“低剂量”考来烯胺用于患有家族性高胆固醇血症的儿童、青少年和年轻人。

"Low dose" colestipol in children, adolescents and young adults with familial hypercholesterolemia.

作者信息

Schlierf G, Mrozik K, Heuck C C, Middelhoff G, Oster P, Riesen W, Schellenberg B

出版信息

Atherosclerosis. 1982 Jan;41(1):133-8. doi: 10.1016/0021-9150(82)90077-6.

Abstract

The effect of colestipol on plasma lipids and lipoproteins was studied in children, adolescents and young adults with familial hypercholesterolemia. O.125 g or 0.25 g/kg body weight were given in randomized sequence for period of 4 weeks. Total cholesterol was lowered by 13 and 18% with the smaller and larger dose , respectively, and LDL cholesterol lowered by 15% with the smaller and 12% with the larger dose. HDL cholesterol rose by 18 an 32%. LDL composition before and during the study was abnormal due to a markedly reduced triglyceride content. "Low-dose" colestipol is less effective lowering total plasma and LDL cholesterol than conventional doses but may, due to very few side effects, by advantageously used in cases of familial hypercholesterolemia when plasma cholesterol levels after dietary management are only 15-20% above normal.

摘要

在患有家族性高胆固醇血症的儿童、青少年和年轻成年人中研究了考来烯胺对血脂和脂蛋白的影响。以随机顺序给予0.125 g或0.25 g/kg体重，为期4周。较小剂量和较大剂量分别使总胆固醇降低了13%和18%，低密度脂蛋白胆固醇较小剂量降低了15%，较大剂量降低了12%。高密度脂蛋白胆固醇分别升高了18%和32%。由于甘油三酯含量明显降低，研究前和研究期间的低密度脂蛋白组成异常。“低剂量”考来烯胺在降低总血浆和低密度脂蛋白胆固醇方面比传统剂量效果差，但由于副作用极少，在饮食管理后血浆胆固醇水平仅比正常水平高15%-20%的家族性高胆固醇血症病例中可能有优势。