Albrink M J
Am J Clin Nutr. 1978 Oct;31(10 Suppl):S277-S279. doi: 10.1093/ajcn/31.10.S277.
The relationship between obesity, insulin resistance, and hyperinsulinemia is briefly reviewed. The possibility is considered that excess insulin secretion is the cause rather than the result of insulin resistance and obesity. Glucose administration is one of the most frequently studied of those factors known to stimulate insulin secretion. Much less well documented is the fact that meals of equal protein, fat, and carbohydrate content may cause different responses of plasma glucose and insulin. An experiment is reported in which the effects of a high-carbohydrate, high-fiber meal administered to seven healthy young adults were compared with the effects of a meal equally high in carbohydrate but composed largely of glucose in liquid formula form. The high-fiber meal caused an insulin rise less than half that caused by the liquid formula meal although the plasma glucose response to the two meals was not significantly different. The hypothesis is proposed that a high-carbohydrate, fiber-depleted diet, high in simple sugars, by repeatedly stimulating an excessive insulin response, may lead to insulin resistance and obesity in susceptible individuals and may play a role in the common occurrence of obesity in industrialized societies.
本文简要回顾了肥胖、胰岛素抵抗和高胰岛素血症之间的关系。文中探讨了一种可能性，即胰岛素分泌过多是胰岛素抵抗和肥胖的原因而非结果。葡萄糖给药是已知刺激胰岛素分泌的因素中研究最为频繁的一种。但同等蛋白质、脂肪和碳水化合物含量的餐食可能导致血浆葡萄糖和胰岛素产生不同反应这一事实，其文献记载则少得多。本文报告了一项实验，该实验比较了给予7名健康年轻成年人一顿高碳水化合物、高纤维餐食的效果与给予一顿碳水化合物含量同样高但主要由液体配方葡萄糖组成的餐食的效果。尽管两餐引起的血浆葡萄糖反应无显著差异，但高纤维餐食引起的胰岛素升高幅度不到液体配方餐食的一半。本文提出一个假设，即高碳水化合物、缺乏纤维且富含单糖的饮食通过反复刺激过度的胰岛素反应，可能会导致易感个体出现胰岛素抵抗和肥胖，并且可能在工业化社会肥胖的普遍发生中起作用。
