因纽特新生儿高胆红素血症。
Hyperbilirubinemia in Inuit neonates.
作者信息
Postl B D, Nelson N, Carson J
出版信息
Can Med Assoc J. 1982 Apr 1;126(7):811-3.
A prospective study was undertaken to determine if Inuit and Caucasian neonates have different patterns of physiologic jaundice. Daily blood samples obtained by heel pricks of Inuit and Caucasian neonates born at the Churchill (Man.) Health Centre were assayed for the total serum bilirubin concentration. The mean peak bilirubin level in the Inuit group was significantly higher than that in the Caucasian group (8.76 v. 6.04 mg/dl [150 v. 103 mumol/l]) and occurred later (on day 3 rather than day 2). Of the Caucasian neonates, those who were breast-fed in hospital had a significantly higher (P less than 0.05) mean peak bilirubin level than those who were not, and among all the neonates who were not breast-fed in hospital the Inuit had a significantly higher mean peak bilirubin level than the Caucasians (7.98 v. 3.64 mg/dl [136 v. 62 mumol/l]). These findings indicate that factors other than breastfeeding, some of which may be genetic, are responsible for the higher and later peak in the serum bilirubin concentration in Inuit neonates.
开展了一项前瞻性研究，以确定因纽特人和白种人新生儿的生理性黄疸模式是否不同。对在丘吉尔（曼省）健康中心出生的因纽特人和白种人新生儿足跟采血获取每日血样，检测血清总胆红素浓度。因纽特人群组的平均胆红素峰值水平显著高于白种人群组（8.76对6.04mg/dl[150对103μmol/l]），且出现时间更晚（在第3天而非第2天）。在白种人新生儿中，住院期间母乳喂养的新生儿平均胆红素峰值水平显著高于未母乳喂养的新生儿（P<0.05），并且在所有住院期间未母乳喂养的新生儿中，因纽特人的平均胆红素峰值水平显著高于白种人（7.98对3.64mg/dl[136对62μmol/l]）。这些发现表明，除母乳喂养外的其他因素，其中一些可能是遗传因素，导致了因纽特人新生儿血清胆红素浓度更高且出现时间更晚的峰值。
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