Fu Y S, Reagan J W, Hsiu J G, Storaasli J P, Wentz W B
Cancer. 1982 Jun 15;49(12):2560-70. doi: 10.1002/1097-0142(19820615)49:12<2560::aid-cncr2820491225>3.0.co;2-g.
Ninety-two primary glandular neoplasms of the uterine cervix, including 51 endocervical adenocarcinomas, four endometrioid carcinomas, and 37 mixed carcinomas, were reviewed to define the biologic significance of pathologic features. Pure adenocarcinomas were found to have a better prognosis from mixed carcinomas of comparable stage (overall five-year survival rate, 49 vs. 36%). Endocervical adenocarcinomas with glandular and papillary patterns had a better prognosis than mucinous adenocarcinomas. When mixed carcinomas were separated into mature, signet-ring, and glassy-cell types, patients with the glassy-cell type had a better five-year survival rate than patients with the other types. However, the long-term prognosis was equally poor. The degree of differentiation as determined by the nuclear features was useful in predicting the outcome in patients with adenocarcinomas. Although the number of cases was small, combined surgery and radiotherapy achieved the best long-term survival for patients with pure adenocarcinomas. This was less apparent for mixed carcinomas.
对92例子宫颈原发性腺性肿瘤进行了回顾性研究，以明确病理特征的生物学意义，这些肿瘤包括51例宫颈管腺癌、4例子宫内膜样癌和37例混合癌。结果发现，在分期相当的情况下，单纯腺癌的预后优于混合癌（总体五年生存率分别为49%和36%）。具有腺管状和乳头状结构的宫颈管腺癌的预后优于黏液腺癌。当将混合癌分为成熟型、印戒细胞型和玻璃样细胞型时，玻璃样细胞型患者的五年生存率高于其他类型患者。然而，其长期预后同样较差。根据细胞核特征确定的分化程度有助于预测腺癌患者的预后。尽管病例数较少，但对于单纯腺癌患者，手术联合放疗可实现最佳长期生存。对于混合癌患者，这种情况不太明显。
