Donaldson S S, Kaplan H S
Cancer Treat Rep. 1982 Apr;66(4):977-89.
An analysis of complications of therapy requires long-term and frequent followup. Reported here is a review of 179 consecutive children with Hodgkin's disease from Stanford University Medical Center who were seen, treated, and followed over a 20-year period. Complications of treatment are related to the extent of disease and the aggressiveness of therapy. Severe complications from radiotherapy are associated with high-dose, extended-field treatment in preadolescent children. Severe chemotherapy-associated complications include immunosuppression, sterility, and secondary oncogenesis. As cure rates are increasingly optimistic among children with Hodgkin's disease, successful treatment with minimal morbidity remains our greatest challenge. Therapy programs require continual refinement utilizing assessment of short- and long-term side effects of treatment.
对治疗并发症的分析需要长期且频繁的随访。本文报告了对斯坦福大学医学中心179例连续的霍奇金病患儿的回顾，这些患儿在20年期间接受了诊治和随访。治疗并发症与疾病范围和治疗的激进程度有关。放疗的严重并发症与青春期前儿童的高剂量、扩大野治疗有关。与化疗相关的严重并发症包括免疫抑制、不育和继发性肿瘤发生。随着霍奇金病患儿的治愈率越来越乐观，以最小的发病率成功治疗仍然是我们最大的挑战。治疗方案需要利用对治疗短期和长期副作用的评估不断完善。
