Toal C B, Sunahara F A
Clin Exp Hypertens A. 1982;4(3):393-410. doi: 10.3109/10641968209060751.
In order to determine the role of the posterior hypothalamus (PH) in the regulation of blood pressure in the hypertensive state an experimental model was utilized. Bolus intra-aortic administration of noradrenaline elicited a dose-related pressor response and subsequent reflex bradycardia in the awake, freely moving spontaneously hypertensive (SHR), renal hypertensive and Wistar Kyoto rats. The reflex bradycardia was greater in the Wistar Kyoto rats than in the two hypertensive models indicating that there is a decrease in baroreceptor sensitivity in the hypertensive state. PH stimulation elicited pressor and tachycardic responses in each group of animals. Moreover, the reflex bradycardia elicited by infusion of noradrenaline was attenuated during PH stimulation. A greater attenuation of the reflex bradycardia occurs in the SHR compared to the other groups at similar stimulation parameters. Evidence is presented to indicate that the PH may be important in the alteration of baroreceptor sensitivity in the SHR.
为了确定下丘脑后部（PH）在高血压状态下血压调节中的作用，采用了一种实验模型。在清醒、自由活动的自发性高血压（SHR）大鼠、肾性高血压大鼠和Wistar Kyoto大鼠中，主动脉内推注去甲肾上腺素可引发剂量相关的升压反应及随后的反射性心动过缓。Wistar Kyoto大鼠的反射性心动过缓比两种高血压模型中的更为明显，这表明在高血压状态下压力感受器敏感性降低。对每组动物进行PH刺激均引发了升压和心动过速反应。此外，在PH刺激期间，去甲肾上腺素输注引发的反射性心动过缓减弱。在相似的刺激参数下，与其他组相比，SHR中反射性心动过缓的减弱更为明显。有证据表明，PH可能在SHR压力感受器敏感性改变中起重要作用。
