Willer J C, Roby A, Gerard A, Maulet C
Eur J Pharmacol. 1982 Feb 19;78(1):117-20. doi: 10.1016/0014-2999(82)90379-x.
The effects of indalpine (a selective 5-HT uptake inhibitor) on the threshold of lower limb nociceptive flexion reflexes were studied (double blind) in humans. After 3 days' administration, indalpine was found to exert a significant naloxone-reversible depression (threshold increased) of the nociceptive reflexes (naloxone and saline were tested double blind). In contrast, no change was found during treatment with placebo. The functional and therapeutic implications of these results are discussed.
在人体中（双盲法）研究了吲哚哌胺（一种选择性5-羟色胺摄取抑制剂）对下肢伤害性屈曲反射阈值的影响。给药3天后，发现吲哚哌胺对伤害性反射产生显著的纳洛酮可逆性抑制作用（阈值升高）（纳洛酮和生理盐水采用双盲法测试）。相比之下，安慰剂治疗期间未发现变化。讨论了这些结果的功能和治疗意义。
