Kalivas P W, Nemeroff C B, Prange A J
Eur J Pharmacol. 1982 Mar 26;78(4):471-4. doi: 10.1016/0014-2999(82)90491-5.
Immunohistofluorescent neurotensin (NT) is found in the ventral tegmental area (VTA), and bilateral injection of NT into the VTA produces an increase in exploratory behaviors. The VTA also contains dopaminergic cell bodies with axonal projections to the nucleus accumbens. In this study it was shown that bilateral microinjection of NT (4.0 micrograms/side) into the nucleus accumbens blocked the behavioral hyperactivity produced by intra-VTA injection of NT (2.5 micrograms/side).
免疫组织荧光法检测发现，腹侧被盖区（VTA）存在神经降压素（NT），向VTA双侧注射NT会使探索行为增加。VTA还含有多巴胺能细胞体，其轴突投射至伏隔核。本研究表明，向伏隔核双侧微量注射NT（4.0微克/侧）可阻断VTA内注射NT（2.5微克/侧）所产生的行为多动。
