伯胺茚三酮反应中的氘同位素效应。
Deuterium isotope effects in the ninhydrin reaction of primary amines.
作者信息
Yu P H, Davis B A
出版信息
Experientia. 1982 Mar 15;38(3):299-300. doi: 10.1007/BF01949352.
PMID:7075719
Abstract
The rate of development of Ruhemann's purple in the ninhydrin reaction of two deuterated primary amines, aa-d2-p-tyramine and aa-d2-beta-phenylethylamine, is significantly reduced. It appears to be a primary isotope effect and indicates that the cleavage of the carbon-hydrogen bond at the a-position is involved in the rate-determining step of the color reaction.
摘要
在茚三酮反应中，两种氘代伯胺，即α,α-d₂-对酪氨酸和α,α-d₂-β-苯乙胺，生成鲁赫曼紫的速率显著降低。这似乎是一种一级同位素效应，表明α位碳氢键的断裂参与了显色反应的速率决定步骤。
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