Saksena S K, Salmonsen R A
Fertil Steril. 1982 May;37(5):686-90.
In the male hamster, administration of 10 or 15 mg/kg/day of gossypol for 5 weeks did not alter the serum concentration of testosterone (T), prolactin (PRL), and luteinizing hormone (LH) or fertility. However, the total sperm population was significantly reduced in the males treated with 15 mg/kg/day of gossypol, and total sterility occurred within 8 weeks. On the other hand, males treated with 10 mg/kg/day of gossypol were sterile after 10 weeks of treatment. The T and total sperm population along the reproductive tract in these infertile males was significantly reduced. During the treatment period no change in body weight or weight of testes or seminal vesicles was observed. A full regaining of fertility, serum T level, and sperm population to the normal range were recorded within 8 nd 14 weeks (15 and 10 mg/kg/day, respectively) after the cessation of treatment.
在雄性仓鼠中，每天给予10或15毫克/千克棉酚，持续5周，并未改变睾酮（T）、催乳素（PRL）和促黄体生成素（LH）的血清浓度，也未影响生育能力。然而，每天接受15毫克/千克棉酚治疗的雄性仓鼠的精子总数显著减少，8周内出现完全不育。另一方面，每天接受10毫克/千克棉酚治疗的雄性仓鼠在治疗10周后不育。这些不育雄性仓鼠生殖系统中的睾酮和精子总数显著减少。在治疗期间，未观察到体重、睾丸或精囊重量的变化。在停止治疗后的8周和14周内（分别为每天15毫克/千克和10毫克/千克），生育能力、血清睾酮水平和精子数量完全恢复到正常范围。
