Shamsuddin A M
Hum Pathol. 1982 May;13(5):510-2. doi: 10.1016/s0046-8177(82)80038-5.
Early neoplastic changes within the nonpolypoid mucosa of the large bowel have been incidentally discovered in two individuals. One of these patients is a 31-year-old man without any known large bowel disease; the other is a 61-year-old woman with diverticulosis. Only small microscopic foci of several neoplastic crypts were observed in otherwise normal-appearing mucosa. This finding lends support to the concept that cells in the crypts, irrespective of their location either in the flat mucosa, polyps, diverticula, or elsewhere, are susceptible to neoplastic transformation.
在两名个体中偶然发现了大肠非息肉样黏膜内的早期肿瘤性改变。其中一名患者是一名31岁男性，无任何已知的大肠疾病；另一名是一名61岁患有憩室病的女性。在外观正常的黏膜中仅观察到几个肿瘤性隐窝的微小显微镜下病灶。这一发现支持了这样一种概念，即隐窝中的细胞，无论其位于扁平黏膜、息肉、憩室或其他部位，都易于发生肿瘤性转化。
