用人源载体血浆制备乙肝多肽胶束。
Preparation of hepatitis B polypeptide micelles from human carrier plasma.
作者信息
Young P, Vaudin M, Dixon J, Zuckerman A J
出版信息
J Virol Methods. 1982 Apr;4(3):177-85. doi: 10.1016/0166-0934(82)90046-5.
Water-soluble protein micelles consisting of the 28,000 (gp28) and 23,00 (p23) molecular weight polypeptide complex of hepatitis B surface antigen can be readily prepared from human plasma containing the surface antigen and other markers of infection with hepatitis B virus. The antigenic activity of the polypeptides was preserved throughout the process of solubilisation and reassociation into micelles. Such preparations are therefore eminently suitable as "second generation" hepatitis B vaccines.
由乙肝表面抗原分子量为28,000（gp28）和23,000（p23）的多肽复合物组成的水溶性蛋白微球，可轻松从含有表面抗原及乙肝病毒感染其他标志物的人血浆中制备得到。在溶解及重新缔合成微球的整个过程中，这些多肽的抗原活性得以保留。因此，此类制剂作为“第二代”乙肝疫苗极为合适。
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