I型假性甲状旁腺功能减退症中血浆对甲状旁腺激素细胞化学生物活性的抑制作用。

Inhibition of cytochemical bioactivity of parathyroid hormone by plasma in pseudohypoparathyroidism type I.

作者信息

Loveridge N, Fischer J A, Nagant de Deuxchaisnes C, Dambacher M A, Tschopp F, Werder E, Devogelaer J P, de Meyer R, Bitensky L, Chayen J

出版信息

J Clin Endocrinol Metab. 1982 Jun;54(6):1274-5. doi: 10.1210/jcem-54-6-1274.

DOI:10.1210/jcem-54-6-1274

PMID:7076801

Abstract

Despite the high circulating levels of immunoreactive PTH in patients with pseudohypoparathyroidism type I (PSPI) the levels of bioactive PTH (bioPTH) have been found to be close to the normal range. To elucidate this dissociation, we have studied the recovery of the biological activity of bovine PTH added to the plasma of patients with either PSPI, or with hypoparathyroidism (PTX), primary hyperparathyroidism (HPT) or of normal subjects. In PSPI (n = 10) the recovery of biological activity was 5.6% +/- 3.6 (mean +/- SEM) whereas in PTX (n = 7), in HPT (n = 4) and in normal subjects (n = 8) it was 79% +/- 5, 75% +/- 9 and 68% +/- 4, respectively. In another PSPI patient, who had undergone total parathyroidectomy, bioPTH was undetectable but the recovery from the plasma of added PTH was 84%. Thus we have found inhibition of PTH bioactivity by plasma of PSPI patients which was absent after parathyroidectomy.

摘要

尽管I型假性甲状旁腺功能减退症（PSPI）患者体内免疫反应性甲状旁腺激素（PTH）的循环水平较高，但生物活性甲状旁腺激素（bioPTH）水平已被发现接近正常范围。为了阐明这种解离现象，我们研究了添加到PSPI患者、甲状旁腺功能减退症（PTX）患者、原发性甲状旁腺功能亢进症（HPT）患者或正常受试者血浆中的牛PTH生物活性的恢复情况。在PSPI患者（n = 10）中，生物活性的恢复率为5.6%±3.6（平均值±标准误），而在PTX患者（n = 7）、HPT患者（n = 4）和正常受试者（n = 8）中，恢复率分别为79%±5、75%±9和68%±4。在另一名接受了甲状旁腺全切除术的PSPI患者中，未检测到bioPTH，但添加的PTH从血浆中的恢复率为84%。因此，我们发现PSPI患者的血浆对PTH生物活性有抑制作用，而甲状旁腺切除术后这种抑制作用消失。