Harrop J S, Bailey J E, Woodhead J S
J Clin Pathol. 1982 Apr;35(4):395-400. doi: 10.1136/jcp.35.4.395.
Over a period of one year, 24500 patients underwent a biochemical profile investigation. Seven hundred and thirty-eight (3%) patients had a plasma calcium concentration of greater than 2.60 mmol/l, and hypercalcaemia was confirmed in 49.8% of those subjects from whom a second fasting sample was received. Primary hyperparathyroidism and malignant disease were the two commonest causes of hypercalcaemia, occurring with equal frequency. The overall incidence of primary hyperparathyroidism in our population was 1:680. Over 75% of the patients with primary hyperparathyroidism appeared to have asymptomatic disease. The merits of including a plasma calcium determination in a biochemical profile would seem to depend particularly on the natural history of asymptomatic primary hyperparathyroidism.
在一年的时间里，24500名患者接受了生化指标检查。738名（3%）患者的血浆钙浓度高于2.60 mmol/L，在收到第二份空腹样本的患者中，49.8%被确诊为高钙血症。原发性甲状旁腺功能亢进症和恶性疾病是高钙血症最常见的两个原因，发生率相同。我们人群中原发性甲状旁腺功能亢进症的总体发病率为1:680。超过75%的原发性甲状旁腺功能亢进症患者似乎患有无症状疾病。在生化指标中纳入血浆钙测定的优点似乎尤其取决于无症状原发性甲状旁腺功能亢进症的自然病程。
