Fortner B R, Danziger R E, Rabinowitz P S, Nelson H S
J Allergy Clin Immunol. 1982 Jun;69(6):484-8. doi: 10.1016/0091-6749(82)90171-3.
The effect of ascorbic acid (AA) on the skin wheal and flare response to histamine and allergen and on the nasal response to allergen was evaluated in eight adults with seasonal allergic rhinitis. The above parameters were measured after 3 days of AA administration (2 gm/day) and again after 3 days of a similar-appearing lactose placebo. An additional study was conducted in which six subjects took 0 (placebo), 1, 2, and 4 gm/day of AA to determine the dose-response effect of AA on histamine skin tests. Overall there was no difference in skin or nasal reactivity between AA and placebo regimens. The findings in this study suggest that AA in relatively high doses would have no beneficial effects on symptoms resulting from allergen exposure and that AA in doses of up to 4 gm/day will not suppress the histamine skin response.
在8名患有季节性过敏性鼻炎的成年人中，评估了抗坏血酸（AA）对皮肤风团及对组胺和过敏原的潮红反应以及对过敏原的鼻部反应的影响。在给予AA（2克/天）3天后测量上述参数，在给予外观相似的乳糖安慰剂3天后再次测量。还进行了一项额外的研究，其中6名受试者分别服用0（安慰剂）、1、2和4克/天的AA，以确定AA对组胺皮肤试验的剂量反应效应。总体而言，AA方案和安慰剂方案在皮肤或鼻部反应性方面没有差异。本研究结果表明，相对高剂量的AA对过敏原暴露引起的症状没有有益影响，且每天剂量高达4克的AA不会抑制组胺皮肤反应。
