Sorg B, Fürstenberger G, Berry D L, Hecker E, Marks F
J Lipid Res. 1982 Mar;23(3):443-7.
The synthesis of 12-O-retinoylphorbol-13-acetate (RPA), an incomplete tumor promoter (second stage promoter) is described. The preparation starts with phorbol-13-acetate-20-tritylether which is acylated by a carbodiimide method to yield its 12-retinoate. The latter is detritylated by acidic methanol to give RPA. Following an analogous procedure, the 4-methyl-ether of RPA is prepared from 4-O-methylphorbol-13-acetate-20-tritylether.
描述了不完全肿瘤启动子（第二阶段启动子）12-O-视黄酰佛波醇-13-乙酸酯（RPA）的合成。制备过程从佛波醇-13-乙酸酯-20-三苯甲基醚开始，通过碳二亚胺法进行酰化反应以生成其12-视黄酸酯。后者用酸性甲醇脱去三苯甲基得到RPA。按照类似的步骤，由4-O-甲基佛波醇-13-乙酸酯-20-三苯甲基醚制备RPA的4-甲基醚。
