Hopkins C A
J Parasitol. 1982 Feb;68(1):32-8.
Following a primary infection with Hymenolepsis diminuta mice were found to be strongly resistant to a challenge infection over a period of eight months. Challenge was by three cysticercoids administered orally, or by inserting into the duodenum one 7-day-old strobilate worm recovered from a donor mouse. Autopsy of immunized mice 6, 8, and 9 days after challenge showed that challenge worms established but that, with few exceptions, only shunted or destrobilated worms remained. Autopsy of recently immunized mice, at daily intervals following challenge, confirmed that transplanted worms establish as well in immunized as in naive mice, and showed that worms grow normally for the first 48 hr but between 48 to 120 hr most worms destrobilate or are lost. In naive mice, transplanted worms survive and grow, approximately doubling their weight daily for at least 6 days (144 hr). The results provide insight to the problem of developing a useful vaccine and the location of memory cells.
在用微小膜壳绦虫进行初次感染后，发现小鼠在八个月的时间里对再次感染具有很强的抵抗力。再次感染是通过口服三只似囊尾蚴，或者将从供体小鼠体内取出的一条7日龄的节片化蠕虫插入十二指肠来进行的。对感染后6天、8天和9天的免疫小鼠进行尸检发现，再次感染的蠕虫能够存活，但除了少数例外，只剩下分流或去节片化的蠕虫。在再次感染后每天对近期免疫的小鼠进行尸检，证实移植的蠕虫在免疫小鼠和未免疫小鼠中都能存活，并且表明蠕虫在最初的48小时内正常生长，但在48至120小时之间，大多数蠕虫会去节片化或消失。在未免疫的小鼠中，移植的蠕虫能够存活并生长，其体重每天大约增加一倍，至少持续6天（144小时）。这些结果为开发有效疫苗的问题以及记忆细胞的定位提供了见解。
