[Therapy of hepatic diseases with alpha-mercaptopropionylglycine].

Thiopronine has been used to treat 88 patients suffering from chronic hepatitis (65), liver cirrhosis in ascitic phase (14), alcoholic hepatosis(5) and acute hepatitis (4). The drug was employed at the attack stage i.v. at a daily dose of 1-2 grams, and at maintenance phase orally at a dose of 0.750-1 gram. It led to a gradual, significant improvement in clinical symptomatology and hepatofunctional haematochemical indices in all chronic forms, only decompensated cirrhosis showing a slight regression. In hepatic forms, normalisation of subjective and objective parameters was particularly fast, between the 4th and 7th days. Tolerance was very good in 98% of cases.