Seibel M M, Levesque L A, Seidenberg E J, Ransil B J
Obstet Gynecol. 1982 Jan;59(1):27-32.
Over the past decade, 24-hour urinary estriol determination has become an integral part of the evaluation and monitoring of high-risk obstetric patients for fetal well-being. This study was undertaken to assess the utility of estriol determinations obtained by simpler collection methods: serum estriol and first morning urine specimens. Serum estriol proved to be an unreliable predictor of 24-hour urine values and of estriol fluctuations. Although the correlation between first morning and 24-hour primary estriol:creatinine ratios was statistically significant (P less than .0001), any single first morning specimen value chosen at random was a poor predictor of the corresponding 24-hour specimen value. However, in the monitoring of high-risk obstetric patients, it is the significant changes with respect to time rather than the absolute estriol levels that are of interest. As the plots of first morning and 24-hour specimen values with respect to time in 8 subjects exhibit time trends of equivalent diagnostic utility, it it concluded that first morning values may be used in place of 24-hour values to monitor high-risk obstetric patients, making the process simple and quicker.
在过去十年中，24小时尿雌三醇测定已成为评估和监测高危产科患者胎儿健康状况不可或缺的一部分。本研究旨在评估通过更简单的采集方法（血清雌三醇和晨尿标本）获得的雌三醇测定的实用性。结果表明，血清雌三醇对于24小时尿液值和雌三醇波动情况是不可靠的预测指标。虽然晨尿与24小时主要雌三醇：肌酐比值之间的相关性具有统计学意义（P小于0.0001），但随机选择的任何单个晨尿标本值对于相应的24小时标本值而言都是较差的预测指标。然而，在监测高危产科患者时，感兴趣的是随时间的显著变化而非雌三醇的绝对水平。由于8名受试者晨尿和24小时标本值随时间的变化曲线显示出具有同等诊断效用的时间趋势，因此得出结论，晨尿值可用于替代24小时值来监测高危产科患者，从而使监测过程更简单、更快捷。
