Krebs H B, Helmkamp B F, Sevin B U, Poliakoff S R, Nadji M, Averette H E
Obstet Gynecol. 1982 Apr;59(4):422-7.
Forty patients with recurrence following radical surgery for early invasive cancer of the cervix were studied. Fifty-eight percent of the recurrences were observed within the first 12 months after surgery and 83% within the first 2 years. The site of recurrence was found to influence diagnosis, symptomatology, clinical findings, prognosis, cause of death, and therapy. The prognosis for patients with recurrent cervical cancer was poor, with only 5 patients (13%) surviving free of disease after 5 years. One patient is presently alive and without disease for more than 2 years. Patients who did not receive a potentially curative course of radiation therapy at the time of diagnosis of the recurrence had a poor prognosis. None of the patients managed by exenterative procedures or chemotherapy survived. Guidelines are suggested for follow-up after primary radical hysterectomy and pelvic node dissection.
对40例早期浸润性宫颈癌根治术后复发的患者进行了研究。58%的复发发生在术后12个月内，83%发生在术后2年内。发现复发部位会影响诊断、症状、临床检查结果、预后、死因和治疗。复发性宫颈癌患者的预后较差，5年后仅有5例患者（13%）无病存活。1例患者目前存活且无病超过2年。复发诊断时未接受可能治愈性放射治疗疗程的患者预后较差。采用盆腔脏器清除术或化疗治疗的患者无一存活。文中提出了原发性根治性子宫切除术和盆腔淋巴结清扫术后随访的指导原则。
