Morray J P, Fox W W, Kettrick R G, Downes J J
Pediatr Res. 1982 Apr;16(4 Pt 1):290-4. doi: 10.1203/00006450-198204000-00009.
Pulmonary function tests were performed in two groups of infants with bronchopulmonary dysplasia; a group less than 7 months of age with severe ventilator-dependent respiratory failure (Group A), and a group 7-22 months of age during resolution of their disease (Group B). Group A patients had significantly elevated minute volume, low specific compliance, elevated inspiratory and expiratory pulmonary resistance, and low functional residual capacity. Group B patients also demonstrated elevated minute volume, whereas specific compliance, inspiratory pulmonary resistance and functional residual capacity were within normal limits, and expiratory pulmonary resistance was only slightly above normal. With the exception of minute volume, the differences between the groups were significant (P less than 0.05). Sequential studies of resistance and compliance over 4-5 months in two patients in the younger group demonstrated values that approached or achieved normal range. It is concluded that pulmonary mechanics improve with age in the infant with severe bronchopulmonary dysplasia.
对两组支气管肺发育不良的婴儿进行了肺功能测试；一组是年龄小于7个月、患有严重呼吸机依赖型呼吸衰竭的婴儿（A组），另一组是年龄在7至22个月、疾病正在缓解期的婴儿（B组）。A组患者的分钟通气量显著升高，比顺应性降低，吸气和呼气肺阻力升高，功能残气量降低。B组患者的分钟通气量也升高，而比顺应性、吸气肺阻力和功能残气量在正常范围内，呼气肺阻力仅略高于正常。除分钟通气量外，两组之间的差异具有统计学意义（P<0.05）。对较年轻组的两名患者在4至5个月内进行的阻力和顺应性的连续研究显示，其数值接近或达到正常范围。得出的结论是，患有严重支气管肺发育不良的婴儿的肺力学随年龄增长而改善。
