Yun J C, Gill J R, Bartter F C, Kelly G D, Keiser H R
Ren Physiol. 1982;5(1):31-43. doi: 10.1159/000172837.
The effect of bradykinin (BK) on renal function was examined in anesthetized dogs with or without treatment with either indomethacin or propranolol. Renal arterial infusion of BK (3 micrograms/min) in control dogs produced a sustained increase in urine flow rate (V), sodium excretion (UNaV), potassium excretion (UKV), and renal plasma flow (RPF) without a consistent change in glomerular filtration rate (GFR) or renin secretion rate (RSR). This increase in salt and water excretion and in RPF could not be blocked with indomethacin (5 mg/kg, followed by 2.1-3.2 mg/kg/h, i.v.). UNaV was 20.8 +/- 7.4 and 123.3 +/- 22.3 muEq/min (mean +/- SEM values) before and after 140 min of infusion of BK (p less than 0.005), respectively. Beta-receptor blockade with propranolol (5 mg/kg, followed by 2.8-3.4 mg/kg/h, i.v.) did not prevent the BK-induced rise in salt and water excretion, or in RPF. UNaV was 26.0 +/- 9.7 and 96.4 +/- 21.5 muEq/min before and after 140 min of infusion of BK (p less than 0.005), respectively. The data suggest that the effects of BK on renal handling of salt and water and on RPF are not mediated by either prostaglandins or beta receptors.
在麻醉犬中，研究了缓激肽（BK）对肾功能的影响，这些犬分为接受或未接受吲哚美辛或普萘洛尔治疗两组。在对照犬中，肾动脉输注BK（3微克/分钟）可使尿流率（V）、钠排泄量（UNaV）、钾排泄量（UKV）和肾血浆流量（RPF）持续增加，而肾小球滤过率（GFR）或肾素分泌率（RSR）无一致变化。吲哚美辛（5毫克/千克，随后以2.1 - 3.2毫克/千克/小时静脉注射）不能阻断这种盐和水排泄以及RPF的增加。输注BK 140分钟前后，UNaV分别为20.8±7.4和123.3±22.3微当量/分钟（平均值±标准误）（p<0.005）。用普萘洛尔（5毫克/千克，随后以2.8 - 3.4毫克/千克/小时静脉注射）进行β受体阻断，不能防止BK诱导的盐和水排泄增加以及RPF增加。输注BK 140分钟前后，UNaV分别为26.0±9.7和96.4±21.5微当量/分钟（p<0.005）。数据表明，BK对肾脏盐和水处理以及对RPF的影响不是由前列腺素或β受体介导的。
