Yun J C, Bartter F C, Kelly G D, Ramwell P
Nephron. 1979;23(5):247-54. doi: 10.1159/000181644.
The interrelationships between acetylcholine (ACH) and prostaglandins in the control of sodium excretion (UNaV) and of renin secretion (RS) were examined in unilaterally-nephrectomized, anesthetized dogs with or without treatment with indomethacin, an inhibitor of prostaglandin synthetase. Inrarenal infusion of ACH (40 microgram/min) in control animals produced diuresis and natriuresis. UNaV was 9.2 +/- 3.1 muEq/min during control periods and was 74.7 +/- 31.6 muEq/min after 40 min of infusion of ACH (p less than 0.05). UNaV was still 48.0 +/- 16.8 muEq/min after 100 min of infusion of ACH (p less than 0.05). RS rate was 930.6 +/- 188.5 U/min during control periods, and was 737.4 +/- 220.3 U/min after 100 min of infusion of ACH (p greater than 0.1). In the dogs treated with indomethacin, the natriuresis produced by ACH could not be sustained. UNaV was 46.6 +/- 12.1 muEq/min before and was 34.7 +/- 12.8 muEq/min 100 min following the infusion of ACH (p greater than 0.1). Arterial plasma renin activity was 3.29 +/- 0.83 ng/ml/h before and was 20.97 +/- 7.78 ng/ml/h after 100 min of infusion of ACH (p less than 0.025). The data suggest that prostaglandins are involved in the sodium excretion and the renin secretion produced by acetylcholine.
在单侧肾切除、麻醉的犬中，使用或不使用前列腺素合成酶抑制剂吲哚美辛，研究了乙酰胆碱（ACH）与前列腺素在钠排泄（UNaV）和肾素分泌（RS）控制中的相互关系。在对照动物中，肾内输注ACH（40微克/分钟）产生利尿和利钠作用。对照期的UNaV为9.2±3.1微当量/分钟，ACH输注40分钟后为74.7±31.6微当量/分钟（p<0.05）。ACH输注100分钟后，UNaV仍为48.0±16.8微当量/分钟（p<0.05）。对照期的RS率为930.6±188.5单位/分钟，ACH输注100分钟后为737.4±220.3单位/分钟（p>0.1）。在使用吲哚美辛治疗的犬中，ACH产生的利钠作用不能持续。ACH输注前UNaV为46.6±12.1微当量/分钟，输注100分钟后为34.7±12.8微当量/分钟（p>0.1）。动脉血浆肾素活性在ACH输注前为3.29±0.83纳克/毫升/小时，输注100分钟后为20.97±7.78纳克/毫升/小时（p<0.025）。数据表明，前列腺素参与了乙酰胆碱产生的钠排泄和肾素分泌。
