组织蛋白酶D活性的脑区分布：大鼠脑室内注射胃酶抑素后其体内活性的抑制情况
Regional brain distribution of cathepsin D activity: its inhibition in vivo following central infusion of pepstatin in the rat.
作者信息
Buccafusco J J, Goldstein B D, Greenbaum L M
出版信息
Res Commun Chem Pathol Pharmacol. 1982 Apr;36(1):157-60.
PMID:7079582
Abstract
Tfhe regional distribution of cathepsin D activity was measured in 10 regiongs of rat brain. The greatest activity was found in the hypothalamo-pituitary axis and in regions surrounding the 4th ventricle. In rats injected centrally with the specific cathepsin D inhibitor, pepstatin, the protease activity was inhibited up to 90% in most brain regions.
摘要
在大鼠脑的10个区域测量了组织蛋白酶D活性的区域分布。在下丘脑 - 垂体轴和第四脑室周围区域发现了最高活性。在向大鼠脑内注射特异性组织蛋白酶D抑制剂胃蛋白酶抑制剂后，大多数脑区的蛋白酶活性被抑制高达90%。
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