Isaksson O G, Jansson J O, Gause I A
Science. 1982 Jun 11;216(4551):1237-9. doi: 10.1126/science.7079756.
Local administration of human growth hormone in vivo to the cartilage growth plate of the proximal tibia of hypophysectomized rats resulted in accelerated longitudinal bone growth. This finding suggests that growth hormone directly stimulates the cells in the growth plate, and does not support the theory that the increase in the plasma concentration of somatomedin that follows growth hormone administration is the cause of this stimulation.
对垂体切除大鼠胫骨近端的软骨生长板进行人生长激素的体内局部给药，导致纵向骨生长加速。这一发现表明生长激素直接刺激生长板中的细胞，并不支持以下理论：生长激素给药后随之而来的生长调节素血浆浓度升高是这种刺激的原因。
