Bonilla E, Schotland D L, Wakayama Y
Ann Neurol. 1978 Aug;4(2):117-23. doi: 10.1002/ana.410040205.
In 6 patients with Duchenne dystrophy, electron microscopical studies of concanavalin A (Con A) binding sites using the peroxidase labeling technique revealed a population of muscle fibers in which the reaction at the cell surface was irregular and patchy in areas larger than 0.5 mu. In 5 control subjects, such focal alterations were not observed and the reaction appeared continuous and regular. The findings indicate focal abnormalities at the muscle cell surface of Con A receptors in Duchenne dystrophy.
在6例杜兴氏肌营养不良患者中，运用过氧化物酶标记技术对伴刀豆球蛋白A（Con A）结合位点进行电子显微镜研究发现，一群肌纤维的细胞表面反应不规则，且在大于0.5微米的区域呈斑片状。在5名对照受试者中，未观察到此类局灶性改变，反应呈现连续且规则。这些发现表明杜兴氏肌营养不良患者的肌细胞表面Con A受体存在局灶性异常。
