Jenkins J, Sugarbaker P H, Gianola F J, Myers C E
Surg Gynecol Obstet. 1982 Jun;154(6):858-62.
Technical aspects of the clinical management of 69 patients who had a Tenckhoff catheter implanted for chemotherapy infusion were reviewed. Catheter placement under local anesthesia was performed using a trochar. Three patients had intestinal perforation. Also, bacterial peritonitis occurred in three patients, an incidence of 10 per cent per catheter year. Peritonitis responded to antibiotic treatment without catheter removal. If the catheter failed to infuse or drain, irrigation and instrumentation were used to reopen the catheter. An absolute indication for catheter removal was infection of the Dacron cuff. Intraperitoneal chemotherapy was thought to be a safe way in which to deliver high concentrations and large amounts of drug to the abdominal cavity. In selected tumors, there may be a significant pharmacologic advantage over conventional routes of administration. Proper catheter insertion and maintenance were required to keep complications of this treatment modality to a minimum.
回顾了69例为进行化疗输注而植入Tenckhoff导管患者的临床管理技术方面。在局部麻醉下使用套管针进行导管置入。3例患者发生肠穿孔。此外，3例患者发生细菌性腹膜炎，每根导管每年的发生率为10%。腹膜炎对抗生素治疗有反应，无需拔除导管。如果导管无法输注或引流，则采用冲洗和器械操作重新开通导管。拔除导管的绝对指征是涤纶套感染。腹腔内化疗被认为是一种向腹腔输送高浓度和大量药物的安全方法。在某些肿瘤中，与传统给药途径相比可能具有显著的药理学优势。需要正确插入和维护导管，以使这种治疗方式的并发症降至最低。
