Mitchell K G, Bradley J A, Ledingham I M, Hamilton D N
Surg Gynecol Obstet. 1982 Jun;154(6):870-4.
A quantitative study of candida colonization of the oral cavity was made in 20 normal persons, 20 patients receiving regular dialysis treatment, 21 patients who underwent operation and were in a general surgical ward and in 20 critically ill patients who had undergone operation and were in an intensive therapy unit. Candida colonization was common in the patients who had operations, and levels were highest in those receiving antibiotics. However, the administration of antibiotics was not the only factor accounting for high candida colonization, since many of the patients studied, receiving regular dialysis treatment and antibiotic therapy, had only low levels of colonization. Candida levels in the oral cavity were highest in the critically ill patients, two of whom had candida infection of the oral cavity and one patient who had systemic candidiasis. Within this group, candida colonization was not significantly different, according to the clinical outcome or the response to recall antigens. This increased candida colonization of the oral cavity may be important in the development of candida infection in these patients.
对20名正常人、20名接受定期透析治疗的患者、21名接受手术且在普通外科病房的患者以及20名接受手术且在重症监护病房的重症患者进行了口腔念珠菌定植的定量研究。念珠菌定植在接受手术的患者中很常见，在接受抗生素治疗的患者中水平最高。然而，抗生素的使用并不是导致念珠菌高定植的唯一因素，因为许多接受定期透析治疗和抗生素治疗的研究患者念珠菌定植水平较低。重症患者口腔中的念珠菌水平最高，其中两名患者有口腔念珠菌感染，一名患者有系统性念珠菌病。在这组患者中，根据临床结果或对回忆抗原的反应，念珠菌定植没有显著差异。口腔念珠菌定植的增加可能对这些患者念珠菌感染的发生很重要。
