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[变形杆菌属细菌对抗生素及其联合用药的敏感性]

[Sensitivity of bacteria of the genus Proteus to antibiotics and their combinations].

作者信息

Nesterova G N, Batanova Z N

出版信息

Antibiotiki. 1978 Oct;23(10):888-92.

PMID:707998
Abstract

Sensitivity of 99 Proteus strains isolated from infants with gastro-intestinal diseases was studied by the method of serial dilutions on the Ploskirev's medium with respect to 19 antibiotics and some of their pair combinations. High resistance levels were registered with respect to penicillin and semi-synthetic penicillins, such as oxacillin, methicillin, ampicillin, as well as oleandomycin, erythromycin, lincomycin and oxytetracycline. The minimum inhibitory concentration for most of the strains was at least 128 gamma/ml. The Proteus strains were more sensitive to aminoglycosides, such as monomycin, neomycin and kanamycin, as well as carbenicillin, cephalosporine, streptomycin, levomycetin, chlortetracycline and novobiocin. Rifampicin, gentamycin and ampicillin combinations with gentamycin had a pronounced antimicrobial effect on Proteus.

摘要

采用连续稀释法,在普洛斯基列夫培养基上,对从患有胃肠疾病的婴儿中分离出的99株变形杆菌菌株,就19种抗生素及其某些配对组合进行了敏感性研究。结果显示,这些菌株对青霉素和半合成青霉素(如苯唑西林、甲氧西林、氨苄西林)以及竹桃霉素、红霉素、林可霉素和土霉素具有高耐药性。大多数菌株的最低抑菌浓度至少为128微克/毫升。变形杆菌菌株对氨基糖苷类抗生素(如莫能霉素、新霉素和卡那霉素)以及羧苄青霉素、头孢菌素、链霉素、氯霉素、金霉素和新生霉素更为敏感。利福平、庆大霉素以及氨苄西林与庆大霉素的组合对变形杆菌有显著的抗菌作用。

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